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Now, configure it by creating a file called postfixadmin/config.local.php with the following content (see postfixadmin/config.inc.php for all available stuff to configure):

config.local.php

<?php
$CONF['database_type'] = 'sqlite';
$CONF['database_name'] = '/home/vmail/db/vmail.sqlite3';
$CONF['encrypt'] = 'dovecot:SHA512';
$CONF['postfix_admin_url'] = 'https://mail.mydomain.com';
$CONF['admin_email'] = 'postmaster@mydomain.com';
$CONF['default_aliases'] = array (
    'abuse' => 'abuse@mydomain.com',
    'hostmaster' => 'hostmaster@mydomain.com',
    'postmaster' => 'postmaster@mydomain.com',
    'webmaster' => 'webmaster@mydomain.com'
);
$CONF['transport'] = 'YES';
$CONF['configured'] = true;
/* vim: set expandtab softtabstop=4 tabstop=4 shiftwidth=4: */

note: when adding new domains, choose “virtual” as transport, and 0 as password expiry.

At this point, you can already create all the mail domains and user accounts you want.